Department of OBGYN

Fen Guo, PhD, FACMG, FCCMG

  • Assistant Professor, Department of Obstetrics, Gynecology & Reproductive Sciences
  • Associate Director, UPMC Genome Center (UGC)
  • Associate Director, UPMC Clinical Genomics Lab (UCGL)

Dr. Fen Guo is a board-certified professional in Laboratory Genetics and Genomics (LGG) by the American Board of Medical Genetics and Genomics (ABMGG) and in Molecular Genetics by the Canadian College of Medical Geneticists (CCMG). She also holds a Laboratory Director Certificate of Qualification in Genetic Testing and Oncology, awarded by the New York State Department of Health.

Education & Training

  • ABMGG Laboratory Genetics and Genomics Fellowship, University of Wisconsin Madison
  • Postdoctoral Fellowship, Schulich School of Medicine & Dentistry, Western University
  • PhD, Biomedical Engineering, Jinan University

Representative Publications

  1. Fen Guo, Ruby Liu, Yinghong Pan, Mary Colasanto, Christin Collins, Madhuri Hegde. Beyond Single Diagnosis: Exploring Multi-Diagnostic Realities in Pediatric Patients through Genome Sequencing. Human Mutation, 2024 Accepted.
  2. ​Arul Joseph Duraisamy, Ruby Liu, Shruti Sureshkumar, Rajiv Rose, Lakshmanan Jagannathan, Fen Guo, Xiangwen Chen-Deutsch, Jorune Balciuniene, Adam Coovadia, Zeq Ma, Cristina da Silva, Babi Nallamilli, Lora Bean, Christin Collins, Madhuri Hegde. Comprehensive genetic testing gives a high diagnostic yield in the Indian sub-continent compared to the western population. In Submission.

  3. Fen Guo, Yinghong Pan; Christin Collins; Lora Bean; Zeqiang Ma; Abhinav Mathur; Cristina Da Silva; Babi Nallamilli; Naga Guruju; Xiangwen Chen-Deutsch; Rizwan Yousaf; Ephrem Chin; Jorune Balciuniene; Madhuri Hedge. Evidence from 2100 index cases supports genome sequencing as a first-tier genetic test. Genet Med. 2024 Jan;26(1):100995.

  4. J. Balciuniene, R. Liu, L. Bean, F. Guo, B.R.R. Nallamilli, N. Guruju, X. Chen-Deutsch, R. Yousaf, K. Fura, E. Chin, A. Mathur, Z. Ma, C. da Silva, C. Collins, M. Hegde. At-Risk Genomic Findings for Pediatric-Onset Disorders From Genome Sequencing vs Medically Actionable Gene Panel in Proactive Screening of Newborns and Children. JAMA Netw Open. 2023 Jul 3;6(7):e2326445.

  5. Ning Jin, Robert F Lera, Rachel E Yan, Fen Guo, Kim Oxendine, Vanessa L Horner, Yang Hu, Jun Wan, Ryan J Mattison, Beth A Weaver, Mark E Burkard. Chromosomal instability upregulates interferon in acute myeloid leukemia. Genes Chromosomes Cancer. 2020 Nov;59(11):627-638.

  6. Levy M, Santos S, Kerkhof J, Stuart A, Aref-Eshghi E, Guo F, HedleyB, Wong H, Rauh M, Feilotter H , Berardi P, Semenuk L, Yang P, Knoll J, Ainsworth P, McLachlin CM, Chin-Yee, Ian, Kovacs, Michael , Deotare U, Lazo-Langner A, Hsia C , Keeney M, Xenocostas A, Howlett C, Lin H, Sadikovic B. Implementation of an NGS-based sequencing and gene fusion panel for clinical screening of patients with suspected hematologic malignancies. Eur J Haematol. 2019 Sep;103(3):178-189.

  7. Liu J, Pampillo M, Guo F, Liu S, Cooperman BS, Farrell I, Dahary D, Gan BS, O'Gorman DB, Smilansky Z, Babwah AV, Leask A. Monitoring collagen synthesis in fibroblasts using fluorescently labeled tRNA pairs. J Cell Physiol. 2014 Sep;229(9):1121-9.

  8. Guo F, Carter DE, Leask A. miR-218 regulates focal adhesion kinase-dependent TGF β signaling in fibroblast. Mol Biol Cell. 2014 Apr;25(7):1151-8.

  9. Guo F, Hutchenreuther J, Carter DE, Leask A. TAK1 is required for Dermal Wound Healing and Homeostasis. J Invest Dermatol. 2013 Jun; 133(6):1646-54.

  10. Guo F, Lin PR, Li YQ, Su XL, Wang DD, Zhou TH. BRPF2, a novel transcript of BRPF1 and their expression in mice tissues. Yi Chuan. 2013 Jan;35(1):79-84.

  11. Guo F, Carter D, Mukhopadhyay A, Leask A. Gingival fibroblasts display reduced adhesion and spreading on extracellular matrix: a possible basis for scarless tissue repair? PLos ONE, 2011;6(11):e27097.

  12. Guo F, Carter D, Leask A. Mechanical tension increases CCN2/CTGF expression and proliferation in gingival fibroblasts via a TGF-β dependent mechanism. PLos ONE, 2011;6(5):e19756.

For full publication list, please visit: https://scholar.google.com/citations?hl=en&user=S56wKGkAAAAJ&view_op=lis...

Clinical Interests/Research Interests

Dr. Guo's clinical interest lies in leveraging her extensive expertise in clinical genetic diagnostics to provide precise and timely diagnoses. Her dedication to quality and excellence fuels her ongoing pursuit of enhancing patient care and clinical genetic diagnostics.

Dr. Guo's research interest centers on employing multi-omics approaches—including genomics, epigenomics, and proteomics—to address rare genetic diseases and investigate their underlying causes. She is dedicated to expanding our knowledge in these fields to improve diagnostics and understand the mechanisms of disease.