Department of OBGYN

Christina J. Megli, MD, PhD

  • Assistant Professor, Department of Obstetrics, Gynecology and Reproductive Sciences
  • OB-GYN Resident Research Director
  • Primary Faculty Magee Womens Research Institute
  • Basic Science Accreditation and Continuous Quality Improvement Faculty Lead

SPECIALTY CERTIFICATION:

American Board of Obstetrics and Gynecology:                                                                    2021    
Board Certified Obstetrician Gynecologist

American Board of Obstetrics and Gynecology                                                                     2024
Board Certified Maternal Fetal Medicine

Representative SERVICE
SMFM Infectious Disease and Emerging Threats Committee          
Physician Scientist Training Program Admissions and Faculty Advisory

Education & Training

  • Maternal-Fetal Medicine Fellowship, UPMC Medical Education, Pittsburgh, PA
  • Obstetrics and Gynecology Residency, Oregon Health and Science University (2017)
  • MD, PhD Geisel School of Medicine at Dartmouth, Hanover, NH (2012)

Representative Publications

  • Megli, C.J., Coyne, C.B. Gatekeepers of Fetus! Characterization of Hoffbauer and maternal placental macrophages. INSIGHT. J Exp Med.2021 Jan 218(1). PMID:33601417 
  • Megli, C.J., Morosky, S., Rajasundaram, D., Coyne, C. Inflammasome signaling in human placental trophoblasts regulates immune defense against Listeria monocytogenes infection. J Exp Med. 2021 Jan. 218(1). PMID: 32976558 Megli, C.J., Coyne, C.B. Infections at the Maternal Fetal Interface: Mechanisms of Molecular Pathogenesis and Defense. Nature Reviews Microbiology. 2021 Aug 25: 1-16. PMID 34433930 
  • Shapero KS, Nauriyal V, Megli C, Berlacher K, El-Dalati, S. Management of infective endocarditis in pregnancy by a multidisciplinary team: a case series. 
  • Yang L, Semmes, E., Ovies, C.  Megli C, Permar, S. Gilner, J. Coyne, C. Innate immune signaling in trophoblast and decidua organoids defines differential antiviral defenses at the maternal-fetal interface. Elife. 2022 Aug 17;11:e79794. 
  • Shapero, K., EL-Salati, S., Berlacher, K. Megli, C. A Single Center Experience of Outcomes of Endocarditis in Pregnancy.   Open Forum Infectious Disease. 2023 Sep 20;10(9):ofad470. PMID: 37779596
  • Megli, C.J., Depuyt, A., Goff, J., Munyoki, S., Hooven, T., Jararevic, E. Diet Influences Community Dynamics Following Vaginal Group B Streptococcus Colonization. Microbiology Spectrum 2024 Jun 4;12(6):e0362323. PMID: 38722155 
  • McMillen, C. Megli, C, Radisic, R. Skvarca, L. Hoehl, R. Boyles, D., McGaughey, J., Bird, B., McElroy, A. Hartman, A. Vaccine strains of Rift Valley fever virus exhibit attenuation at the maternal-fetal placental interface. J. Virol. 2024 Aug 20;98(8):e0098324. PMID: 39016561
  • Megli CJ, Carlin SM, Giacobe EJ, Hillebrand GH, Hooven TA. Virulence and pathogenicity of group B Streptococcus: Virulence factors and their roles in perinatal infection. Virulence. 2025 Dec;16(1):2451173. doi: 10.1080/21505594.2025.2451173. Epub 2025 Jan 23. PMID: 39844743
  • Megli CJ, Beigi R. Chapter 51: Fetal and Neonatal Infection. Creasy & Resnik’s Maternal Fetal Medicine 9e .Lockwood, C., Moore, T., Copel, J.,  Silver, R., Resnik, R., Dugoff L., and Louis, J.  (Ed) Elsevier. 2023
  • Proctor, C, Megli, CJ. Maternal and Perinatal Infection in Pregnancy.  Gabbe Obstetrics: Normal and Problem Pregnancies 9e 2025


Link to publications: 
https://www.ncbi.nlm.nih.gov/myncbi/christina.megli.1/bibliography/public/